TSH is often the first test doctors use to determine whether you have too little or too much thyroid hormones. High TSH is often linked to an underactive thyroid or hypothyroidism. Read on to learn about the causes, symptoms, and health effects of high TSH levels.
Causes listed below are commonly associated with higher TSH. However, while an abnormal TSH test can indicate there is a problem, it can’t pinpoint the cause. In addition, a result that’s higher than normal doesn’t necessarily mean that you have a health condition needing treatment.
Your doctor will usually follow this result with additional testing to investigate why your TSH is high. Work with your doctor or another health care professional to get an accurate diagnosis.
TSH often increases in response to an underactive thyroid gland (primary hypothyroidism) .
Thyroid hormones are made from the chemical iodine, which humans need to get from the food they eat. Not getting enough iodine in the diet (severe iodine deficiency) can lead to hypothyroidism, and may even cause goiters (a large swelling of the thyroid gland that bulges out from the neck) [4, 5].
Many studies also show that excessive iodine intake can also lead to hypothyroidism (>150 μg for people with existing thyroid diseases, or >1,100 μg for health individuals) .
For example, children living in an area with abnormally high iodine concentrations in their drinking water show higher rates of thyroid dysfunction (increased levels of TSH and thyroid antibodies) .
Overeating is another common cause of thyroid dysfunction. A study found that chronic overeating led to an increase in T3 levels over both the short- and long-term (from 3 weeks up to 7 months) .
Two separate studies have shown that among women, overweight and obese ones have higher TSH levels than normal-weight patients. This includes people with higher overall body weight and body mass index (BMI), larger waist size, and higher body fat percentage [13, 12].
Another study found that healthy young women with high TSH levels were found to be twice as likely to have metabolic syndrome (a condition that causes obesity, high blood pressure, and high levels of sugar, fat, and cholesterol in the blood) when compared to women with lower TSH levels .
The link between TSH and obesity doesn’t apply only to women, either: two large-scale studies have shown that higher TSH levels are associated with a higher BMI in both male and female patients alike [15, 16].
TSH is involved in the weight of children as well. Obese and overweight children have higher TSH levels, and these high levels are linked to increases in cholesterol, fat, and blood pressure .
Radiation therapy in the head and neck area can damage the thyroid gland and thereby cause hypothyroidism. This, in turn, increases TSH levels .
Some toxins, drugs, and supplements can increase TSH, including:
- Lithium therapy [21, 22, 23, 24, 25].
- Opioids, including morphine, methadone, and buprenorphine [26, 27, 28, 29, 30].
- Metyrapone (Metopirone), used to treat Cushing’s syndrome .
- Arsenic .
- Perchlorates found in rocket fuels .
- Dopamine inhibitors (metoclopramide, domperidone, sulpiride, monoiodotyrosine) [34, 35].
Certain rare genetic disorders can result in elevated TSH levels .
TSH levels normally increase as we age .
High TSH is commonly caused by hypothyroidism (low thyroid hormone levels), in which case a person may experience:
- Fatigue 
- Constipation 
- Weight gain 
- Depression 
- Anxiety 
- Memory problems [40, 41, 42]
- Attention issues 
- Dry skin 
- Sensitivity to the cold 
However, high TSH can also be caused by conditions other than hypothyroidism, in which case symptoms will vary depending on the underlying condition.
A study with over 30k people revealed that people with higher TSH levels tended to also have higher blood pressure .
TSH has also been linked to high blood pressure in children, especially in overweight children .
A meta-analysis of data from over 55k patients found that people with very high TSH levels had a higher chance of developing (and dying from) heart disease .
Both high bad cholesterol and low good cholesterol are known risk factors for heart disease.
A study showed that higher TSH levels were correlated with faster cancer progression in 126 patients with a specific type of thyroid cancer (papillary thyroid microcarcinoma) .
High TSH levels may have different effects depending on one’s age.
There are several studies that suggest slightly elevated TSH may be beneficial in seniors when it comes to:
- Cognitive function [55, 60, 61, 62]
- Bone health [63, 64, 65]
- Physical health and shape 
- Longevity [67, 68]
A high TSH test can indicate there is a problem, but can’t pinpoint the cause. That’s because a high TSH can be a result of many different health conditions that all need different approaches and treatments.
It’s important to work with your doctor to find out what’s causing your high TSH levels and then to treat any underlying conditions.
Trying to artificially decrease your TSH with lifestyle modifications or supplements likely won’t address the underlying condition and may instead make it worse.
If you have an underactive thyroid (hypothyroidism), treatment will depend on your hormone levels, medical history, and your signs and symptoms. While subclinical hypothyroidism with mildly increased TSH levels is usually not treated, the standard treatment for other forms of hypothyroidism involves a daily dose of synthetic thyroid hormone medication that can restore thyroid hormone levels and reverse the signs and symptoms of hypothyroidism. But keep in mind that it may take some time to adjust the dosage of thyroid hormones so they are right for you .
If you have digestive issues, stay away from offending foods. A study suggests that avoiding dairy products may help decrease TSH levels in people who are lactose intolerant . Similarly, maintaining a strict gluten-free diet may help decrease TSH in people with celiac disease .
This post is part of a three-part series about TSH. Check out: