Evidence Based This post has 23 references
3.7 /5

High Anti-CCP? Natural Ways to Reduce Inflammation

Written by Puya Yazdi, MD | Last updated:
Medically reviewed by
Nicole Craven, MD | Written by Puya Yazdi, MD | Last updated:

SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. We believe that the most accurate information is found directly in the scientific source.

We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic.

Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.

All of our content is written by scientists and people with a strong science background.

Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again.

Our goal is to not have a single piece of inaccurate information on this website. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at support@selfhacked.com.

Note that each number in parentheses [1, 2, 3, etc.] is a clickable link to peer-reviewed scientific studies. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract.

Some researchers have theorized that high anti-CCP antibody levels can be used to both identify and reduce inflammation in rheumatoid arthritis. Learn more here.

What is Anti-CCP?

Anti-CCP is a type of autoimmune antibodies against citrullinated proteins (CCP). Anti-CCP antibodies are abundant in rheumatoid arthritis, and tests measuring anti-CCP have a specificity of about 96% [1].

Natural Factors That May Decrease Inflammation in Joint Disease

It is important to remember that levels of the antibody are not directly linked to disease activity, but since anti-CCP antibodies are still believed to play a role in the destruction of the joints, some studies use them to try and understand or decipher substances that might affect disease progression [2].

That is to say: the following substances have been found to decrease both inflammation and, by proxy, anti-CCP levels. There is no indication of whether these strategies might directly reduce anti-CCP.

Possibly Effective

1) Address Gum Disease

Gum disease (periodontal disease) is often caused by an infection by the bacteria P. gingivalis [3].

Several studies have found that rheumatoid arthritis patients are more likely to have gum disease as well as more severe forms of the disease [4, 5, 6, 7, 8].

Some research suggests that oral bacteria such as P. gingivalis directly contribute to the development of rheumatoid arthritis [9].

Higher levels of antibodies to P. gingivalis are linked to higher levels of citrulline [3].

Dental treatment that removed P. gingivalis reduced the production of citrulline in 55 RA patients [3].

Underlying gum disease and poor dental hygiene are associated with rheumatoid arthritis and high anti-CCP levels.

2) Quit Smoking

Smoking increases the risk of testing positive for anti-CCP antibody levels and is also associated with higher levels and more severe disease status in Rheumatoid Arthritis patients [10, 11, 12, 13].

Smoking increases the citrullination of proteins that can trigger an autoimmune reaction [14].

Quitting smoking may help reduce inflammation in people with rheumatoid arthritis and high anti-CCP levels.

Insufficient Evidence

The following substances have shown promise against rheumatoid arthritis and high anti-CCP in limited, low-quality clinical studies; there is currently insufficient evidence to support their use in this context, and they should never replace what your doctor prescribes. Remember to talk to your doctor before starting any new supplement or making significant changes to your diet.

3) Vitamin D

Vitamin D deficiency is linked to both a greater risk of developing rheumatoid arthritis and more severe arthritis symptoms such as pain, swelling, and inflammation in existing patients [15, 16].

In a study of over 200 people, lower vitamin D levels were linked to higher anti-CCP antibody levels [17].

Vitamin D may help lower anti-CCP antibodies by suppressing overactive immune cells that attack the body’s own proteins and tissues [17].

Vitamin D deficiency is linked to both rheumatoid arthritis and higher anti-CCP antibodies.

4) Omega-3 Fatty Acids

In case studies, higher omega-3 fatty acid levels are associated with a lower risk of anti-CCP antibody production [18, 19].

Omega-3 fats help by reducing inflammation that can increase the citrullination of proteins leading to an immune system reaction and increased anti-CCP [20, 21].

Studies show that in anti-CCP positive patients, higher levels of omega-3s slowed the progression of inflammatory arthritis symptoms, but further study is needed [20, 22].

Omega-3’s reduced inflammation in people with high anti-CCP, but more studies are needed.

5) Wormwood

One study of 127 rheumatoid arthritis patients looked at the effect of taking sweet wormwood (Artemisia annua) or a placebo in addition to standard immunosuppressive drugs. Those given wormwood saw a nearly 10% greater reduction in anti-CCP antibodies and a greater reduction in painful and swollen joints after 48 weeks [23].

About the Author

Puya Yazdi

Dr. Puya Yazdi is a physician-scientist with 14+ years of experience in clinical medicine, life sciences, biotechnology, and nutraceuticals.
As a physician-scientist with expertise in genomics, biotechnology, and nutraceuticals, he has made it his mission to bring precision medicine to the bedside and help transform healthcare in the 21st century. He received his undergraduate education at the University of California at Irvine, a Medical Doctorate from the University of Southern California, and was a Resident Physician at Stanford University. He then proceeded to serve as a Clinical Fellow of The California Institute of Regenerative Medicine at The University of California at Irvine, where he conducted research of stem cells, epigenetics, and genomics. He was also a Medical Director for Cyvex Nutrition before serving as president of Systomic Health, a biotechnology consulting agency, where he served as an expert on genomics and other high-throughput technologies. His previous clients include Allergan, Caladrius Biosciences, and Omega Protein. He has a history of peer-reviewed publications, intellectual property discoveries (patents, etc.), clinical trial design, and a thorough knowledge of the regulatory landscape in biotechnology. He is leading our entire scientific and medical team in order to ensure accuracy and scientific validity of our content and products.


1 Star2 Stars3 Stars4 Stars5 Stars
(6 votes, average: 3.67 out of 5)

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.